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标题:Bioprocess optimization for cell culture based influenza vaccine production
时间:2021-08-01 10:59:33
DOI:10.1016/j.vaccine.2011.01.081
大小:796 kb
页数:10 PAGES
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目录:
  • Bioprocess optimization for cell culture based influenza vaccine production
    • Introduction
    • Materials and methods
      • Cell line
      • Virus strains
      • Static culture conditions (cell thaw and expansion)
      • Bioreactor culture conditions
      • Virus infection
      • Analytical methods
    • Results
      • Effect of time of infection on virus replication kinetics
      • Effect of time of infection on the level of virus production
      • Effect of multiplicity of infection on ca A/Wisconsin/67/05 virus production
      • Effect of very low multiplicity of infection on virus replication kinetics and yield
      • Applications of MOI optimization on LAIV vaccine production
    • Discussion
    • Acknowledgements
    • References

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