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时间:2021-07-22 10:54:36
DOI:10.1038/s41568-018-0006-7
PMID:29700396
大小:1342 kb
页数:19 PAGES
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目录:
  • A history of exploring cancer in context
    • Establishing the TME field
      • Angiogenesis
      • Immunity and inflammation
        • Inflammation and cancer
        • Presence and functions of lymphocytes in the TME
        • Presence of myeloid cells in the TME
        • Presence and functions of immunoglobulins in the TME
        • Presence and functions of chemokines in the TME
    • Tumour–TME crosstalk
      • ECM and biomechanics
      • Cancer-associated fibroblasts
      • Cancer stem cell niche
      • Metabolomics: focus on hypoxia
      • Microbiota
    • The metastatic microenvironment
      • The pre-metastatic niche
      • Site-specific metastasis
    • Therapeutic implications
      • Cancer therapy and the TME
      • Targeting tumour–TME interactions
      • Imaging the tumour microenvironment
      • Challenges in targeting the tumour microenvironment
    • Perspectives
      • Microenvironmental control of tumours and metastasis: a non-canonical mechanism for antitumour resistance
    • Acknowledgements
    • Fig. 1 Timeline of tumour microenvironment research.
    • Fig. 2 The primary tumour and metastatic microenvironments regulate tumour progression by distinct pathways.
    • Fig. 3 The deleterious influence of tumour–tumour microenvironment interactions on therapy.
    • Table 1 A representative panel of FDA-approved agents that target the tumour microenvironment.

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