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标题:ErbB Receptors and Cancer
时间:2021-04-08 14:25:13
DOI:10.1007/978-1-4939-7219-7_1
大小:670 kb
页数:34 PAGES
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目录:
  • Chapter 1: ErbB Receptors and Cancer
    • 1 Introduction
    • 2 ErbB Receptors
      • 2.1 EGFR
      • 2.2 ErbB2
      • 2.3 ErbB3
      • 2.4 ErbB4
    • 3 Ligands of ErbB Receptors
    • 4 Receptor-Ligand Interaction and Receptor Dimerization
    • 5 Phosphorylation of C-Terminal Tyrosine Residues
    • 6 Activation of Downstream Signaling Proteins and the Control of Cell Functions
      • 6.1 Ras and ERK
      • 6.2 PLC-gamma1
      • 6.3 PI3K and Akt
      • 6.4 STAT and Src
    • 7 Other Signaling Pathways Mediated by ErbB Receptors
      • 7.1 Signaling from Endosomes
      • 7.2 Nuclear Translocation and the Role of ErbB Receptors in the Induction of Gene Expression
      • 7.3 EGFR Signaling at Different Phases of the Cell Cycle
      • 7.4 Transactivation of G Protein-Coupled Receptors (GPCRs)
    • 8 Implications in Human Cancer
      • 8.1 EGFR
      • 8.2 ErbB2
      • 8.3 ErbB3
      • 8.4 ErbB4
    • 9 Conclusion
    • References

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