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标题:A novel biomarker Linc00974 interacting with KRT19 promotes proliferation and metastasis in hepatocellular carcinoma
时间:2021-04-05 23:13:44
DOI:10.1038/cddis.2014.518
PMID:25476897
大小:4444 kb
页数:14 PAGES
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目录:
  • A novel biomarker Linc00974 interacting with KRT19 promotes proliferation and metastasis in hepatocellular carcinoma
    • Main
    • Results
      • Linc00974 was upregulated with a high correlation with KRT19 in HCC
      • Linc00974 promoted cell proliferation and invasion in vitro
      • Linc00974 induced an inhibition of tumor growth and metastasis in vivo
      • Linc00974 affected KRT19 expression by acting as a competing endogenous RNA (ceRNA) interacting with miR-642
      • NOTCH and TGF-β signal pathways were promoted by the upregulation of KRT19 induced by Linc00974
      • Linc00974 acted as a biomarker in predicting the growth and metastasis of HCC
    • Discussion
    • Materials and Methods
      • Patient samples
      • Quantitative real-time PCR
      • Western blotting
      • Immunohistochemical assay
      • Cell proliferation and invasion assay
      • Luciferase reporter gene assay
      • The subcutaneous xenotransplantation model
      • The metastasis model
      • RNA immunoprecipitation
      • Microarray assay detection and bioinformatics analyses
      • ROC curve analysis and cluster analysis
      • Statistical analysis
    • Acknowledgements
    • Notes
    • References

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