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标题:Icariside II attenuates cerebral ischemia/reperfusion-induced blood–brain barrier dysfunction in rats via regulating the balance of MMP9/TIMP1
时间:2021-03-30 18:18:37
DOI:10.1038/s41401-020-0409-3
PMID:32488170
大小:5499 kb
页数:11 PAGES
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目录:
  • Icariside II attenuates cerebral ischemia/reperfusion-induced blood–nobreakbrain barrier dysfunction in rats via regulating the balance of MMP9/TIMP1
    • Introduction
    • Materials and methods
      • Animals and drug
      • Rat MCAO model
      • ICS II administration and groups
      • Assessment of BBB integrity
      • Histological examination and Nissl staining
      • Immunohistochemical staining
      • Western blot analysis
      • TUNEL staining
      • Molecular docking
      • Statistical analysis
    • Results
      • ICS II attenuated BBB disruption after cerebral I/R injury in rats
      • ICS II suppressed damage to the hippocampus, cortex and striatum after cerebral I/R injury
      • ICS II inhibited cerebral I/R-induced neuronal loss in the hippocampus and cortex
      • ICS II attenuated the MMP/TIMP1 balance in cerebral I/R-induced injury
      • ICS II improved BBB integrity after cerebral I/R by upregulating the expression of tight junction-related proteins
      • ICS II inhibited cerebral I/R-induced neural apoptosis in rats
      • ICS II bound to and inhibited MMP2/9
    • Discussion
    • Acknowledgements
    • Author contributions
    • ADDITIONAL INFORMATION
    • References

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