在线客服: 点击这里给我发消息  新用户使用步骤:会员注册→充值→重新登入→进入资源
标题:Development of a Subcellular Semimechanism-Based Pharmacokinetic/Pharmacodynamic Model to Characterize Paclitaxel Effects Delivered by Polymeric Micelles
时间:2021-03-22 20:19:10
DOI:10.1016/j.xphs.2018.10.062
PMID:30414867
大小:1257 kb
下载: 点击下载
预览:

浏览器不支持嵌入PDF阅读,打开新页面在线阅读

目录:
  • Development of a Subcellular Semimechanism-Based Pharmacokinetic/Pharmacodynamic Model to Characterize Paclitaxel Effects D ...
    • Introduction
    • Materials and Methods
      • Chemicals and Cell Lines
      • Preparation and Characterization of PTX-Loaded Micelles
      • Subcellular Distribution Study
      • In Vitro Pharmacodynamic Study
        • Tubulin Polymerization and G2/M Arrest Determination by Flow Cytometer Analysis
        • Cell Growth Inhibition
      • PK/PD Modeling Based on Cellular Assay System
    • Results
      • Characterization of PM-PTX
      • Intracellular PTX Drug Distribution and Pharmacokinetics
      • Pharmacodynamic Effects of Intracellular PTX-PM
    • Discussion
    • Conclusion
    • Acknowledgments
    • References

本页内容由网络收集而来,版权归原创者所有,如有侵权请及时联系