| 标题： | TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability |
| 时间： | 2021-02-23 22:19:41 |
| DOI： | 10.1016/j.canlet.2019.12.042 |
| 大小： | 1878 kb |
| 页数： | 10 PAGES |
| 下载： | 点击下载 |
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目录：
- TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability
- Introduction
- Material and methods
- Cell lines and infection
- Expression plasmids
- Immunoprecipitation and mass spectrometry analysis
- Co-immunoprecipitation and Western blot
- Silencing experiments
- RNA isolation and quantitative PCR (qPCR)
- Fluorescence and confocal microscopy
- Live-cell imaging
- Cell synchronization
- Flow cytometric analysis
- Metaphase spreads and karyotyping
- Results
- TRIM8 physically interacts with mitotic proteins
- Disentangling TRIM8 in mitotic spindle processes
- TRIM8 silencing slows down mitosis progression
- TRIM8 is required for chromosomal stability
- Discussion
- Author contribution
- mk:H1_21
- Acknowledgments
- Supplementary data
- References
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