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标题:Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
时间:2021-02-23 17:11:58
DOI:10.1016/j.cell.2015.08.016
大小:3267 kb
页数:15 PAGES
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目录:
  • Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
    • Introduction
    • Results
      • Tumors Glucose-Restrict T Cells, Altering Their Metabolism and Function
      • Tumor-Imposed Nutrient Restrictions Can Lead to T Cell Hyporesponsiveness, Even When Tumors Are Highly Antigenic
      • Nutrient Competition between Tumors and T Cells Can Regulate Cancer Progression
      • Checkpoint Blockade Therapy Corrects Nutrient Restriction Experienced by T Cells in a Progressing Tumor
      • PD-L1 Directly Regulates Tumor Metabolism
    • Discussion
    • Experimental Procedures
      • Mice and Tumor Transplantation
      • In Vivo Checkpoint Blockade Treatment
      • Metabolism Assay
      • Transduction
      • Glucose Assay
      • Statistical Analysis
    • Supplemental Information
    • Author Contributions
    • Acknowledgments
    • References

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