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标题:Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death
时间:2021-02-23 16:32:44
DOI:10.1038/s41467-020-18745-6
大小:6548 kb
页数:13 PAGES
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目录:
  • Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death
    • Results
      • Preparation and characterization of ROS nanoscavenger
      • Investigation of PEG-TECM-NS/OLE-induced ICD and in’vitro anticancer efficacy
      • PEG-TECM-NS activated immunogenicity of tumour cells
      • In vivo antitumour activity of PEG-TECM-NS/OLE
    • Methods
      • Preparation and characterization of nanoscavengers
      • ELISA protocol to determine collagen binding constant
      • Cell apoptosis detection
      • Animal model
      • BMDC culture and stimulation
      • T-cell proliferation assay
      • Tumour-infiltrating lymphocytes analysis
      • In vivo PET imaging
      • In vivo MR imaging
      • In vivo antitumour therapy
      • Orthotopic CT26 tumour model establishment
      • Statistics and reproducibility
      • Statistical analysis
    • Reporting summary
    • Data availability
    • References
    • Acknowledgements
    • Author contributions
    • Competing interests
    • Additional information

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