Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway - 学霸图书馆

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标题：	Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway
时间：	2021-02-23 16:17:50
DOI：	10.1016/j.ccell.2018.11.006
大小：	5199 kb
页数：	23 PAGES
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目录：

Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway
- Introduction
- Results
  - FAT1 Loss Is Associated with Poor Outcome on CDK4/6i Therapy
  - FAT1 Loss Promotes CDK4/6i Resistance
  - FAT1 Loss Leads to Resistance to CDK4/6i
  - FAT1 Loss Induces the Expression of CDK6
  - FAT1 Regulates CDK6 via the Hippo Pathway
  - Hippo Pathway Alterations and Drug Resistance
- Discussion
- Supplemental Information
- Acknowledgments
- Author Contributions
- Declaration of Interests
- References
- STAR★Methods
  - Key Resources Table
  - Contact for Reagent and Resource Sharing
  - Experimental Model and Subject Details
    - Human Subjects
    - Cell Lines
    - In Vivo Tumor Models
  - Method Details
    - Prospective Sequencing and Analysis
    - Quantitative RT-PCR and Chromatin Immunoprecipitation (ChIP)
    - Lentiviral Infection and Generation of Stable Cell Lines
    - Cloning and Plasmids
    - Immunohistochemistry (IHC)
    - Immunofluorescent and Confocal Microscopy
    - Cell Proliferation
    - Immunoblotting
    - RNA Sequencing
  - Quantification and Statistical Analysis
    - Functional Evaluation of Alterations
      - Integrative Pathway Analysis
    - Statistical Analysis
    - Analysis of RNA Sequencing Data
    - Statistical Analysis for Experimental Data
  - Data and Software Availability

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