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标题:Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway
时间:2021-02-23 16:17:50
DOI:10.1016/j.ccell.2018.11.006
大小:5199 kb
页数:23 PAGES
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目录:
  • Loss of the FAT1 Tumor Suppressor Promotes Resistance to CDK4/6 Inhibitors via the Hippo Pathway
    • Introduction
    • Results
      • FAT1 Loss Is Associated with Poor Outcome on CDK4/6i Therapy
      • FAT1 Loss Promotes CDK4/6i Resistance
      • FAT1 Loss Leads to Resistance to CDK4/6i
      • FAT1 Loss Induces the Expression of CDK6
      • FAT1 Regulates CDK6 via the Hippo Pathway
      • Hippo Pathway Alterations and Drug Resistance
    • Discussion
    • Supplemental Information
    • Acknowledgments
    • Author Contributions
    • Declaration of Interests
    • References
    • STAR★Methods
      • Key Resources Table
      • Contact for Reagent and Resource Sharing
      • Experimental Model and Subject Details
        • Human Subjects
        • Cell Lines
        • In Vivo Tumor Models
      • Method Details
        • Prospective Sequencing and Analysis
        • Quantitative RT-PCR and Chromatin Immunoprecipitation (ChIP)
        • Lentiviral Infection and Generation of Stable Cell Lines
        • Cloning and Plasmids
        • Immunohistochemistry (IHC)
        • Immunofluorescent and Confocal Microscopy
        • Cell Proliferation
        • Immunoblotting
        • RNA Sequencing
      • Quantification and Statistical Analysis
        • Functional Evaluation of Alterations
          • Integrative Pathway Analysis
        • Statistical Analysis
        • Analysis of RNA Sequencing Data
        • Statistical Analysis for Experimental Data
      • Data and Software Availability

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