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标题:How formaldehyde reacts with amino acids
时间:2021-02-23 14:45:56
DOI:10.1038/s42004-019-0224-2
大小:1005 kb
页数:15 PAGES
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目录:
  • How formaldehyde reacts with amino acids
    • Results
      • Product identification in reactions of AAs and HCHO
      • pH and concentration dependence studies
      • Assessing product stabilities
      • Competition between Cys and different AAs for reaction with HCHO
      • Comparison of the reactivity of Cys with HCHO using different electrophiles
      • Reductive Nα-methylation
    • Discussion
    • Methods
      • General methods
      • Standard conditions reaction setup
      • Adjusted pH reactions
      • pH dependent equilibria experiments
      • Stability assays using 1,3-cyclohexadione
      • Lyophilisation to test stability of HCHO adducts
      • Using 13C labelled HCHO to test for exchange of HCHO adducts
      • Competition assays
      • Spectator AA experiments
      • Reductive amination
      • Product characterisation
      • Cysteine products
      • Homocysteine products
      • Penicillamine products
      • Serine product
      • Threonine product
      • allo-Threonine product
      • Homoserine product
      • Asparagine products
      • Glutamine product
      • Histidine products
      • Tryptophan products
      • Arginine products
      • Ornithine products
      • Lysine product
      • Cysteine and acetaldehyde products
      • Cysteine and acetone product
      • Cysteine and glyoxal products
      • Cysteine and methylglyoxal products
    • Data availability
    • References
    • Acknowledgements
    • Author contributions
    • Competing interests
    • Additional information

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