在线客服: 点击这里给我发消息  新用户使用步骤:会员注册→充值→重新登入→进入资源
标题:Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis
时间:2021-02-23 01:04:55
DOI:10.1016/j.semcdb.2017.11.011
PMID:29127046
大小:1645 kb
页数:15 PAGES
下载: 点击下载
预览:

浏览器不支持嵌入PDF阅读,打开新页面在线阅读

目录:
  • Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenera...
    • 1 Introduction
    • 2 Function of the Myogenic Regulatory Factors during developmental myogenesis
      • 2.1 Somitic differentiation into sclerotome, dermomyotome, myotome and syndetome
      • 2.2 MRFs control phases of developmental myogenesis
      • 2.3 Viable mice can be generated after inactivation of Myf5, MyoD or MRF4, but not Myogenin
      • 2.4 MYF5, MYOD and MRF4 overlap in directing myogenic specification, while Myogenin is indispensible for myogenic differen...
      • 2.5 MRF-directed genetic cell ablation indicates that myoblasts express both Myf5 and MyoD
    • 3 Role of the Myogenic Regulatory Factors in mature muscle
      • 3.1 MRF4 is the most highly expressed MRF in healthy mature muscle
      • 3.2 MYOD and Myogenin can influence MyHC content and metabolic properties of myofibres
      • 3.3 MRF4 has a homeostatic role in repressing MEF2 to suppress hypertrophy
    • 4 Myf5, MyoD and MRF4 are expressed during satellite cell specification
      • 4.1 Satellite cells are derived from Pax3/Pax7 stem cells in trunk and limb
      • 4.2 The Myf5, MyoD and Mrf4 loci are active during satellite cell specification
      • 4.3 Satellite cell specification begins during embryogenesis
      • 4.4 Individual MRFs are dispensable for satellite cell specification
    • 5 Myf5 expression is maintained in quiescent satellite cells
      • 5.1 Myf5 has been/is expressed in essentially all quiescent satellite cells
      • 5.2 Does lack of Myf5 expression identify satellite ‘stem’ cells?
    • 6 Myogenic Regulatory Factor function in satellite cells during regenerative myogenesis
      • 6.1 All MRFs are re-expressed during regenerative myogenesis
      • 6.2 MYF5 and MYOD control timely myogenic progression in satellite cells during regeneration
      • 6.3 MRF expression dynamics in ex vivo models of regenerative myogenesis
      • 6.4 MYF5 and MYOD are cell cycle regulated
      • 6.5 MYF5 and MYOD control satellite cell proliferation
    • 7 Summary
    • 8 Future perspectives
    • Competing financial interests
    • Acknowledgements
    • Appendix A Supplementary data
    • References

本页内容由网络收集而来,版权归原创者所有,如有侵权请及时联系