| 标题： | Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenerative myogenesis |
| 时间： | 2021-02-23 01:04:55 |
| DOI： | 10.1016/j.semcdb.2017.11.011 |
| PMID： | 29127046 |
| 大小： | 1645 kb |
| 页数： | 15 PAGES |
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目录：
- Function of the myogenic regulatory factors Myf5, MyoD, Myogenin and MRF4 in skeletal muscle, satellite cells and regenera...
- 1 Introduction
- 2 Function of the Myogenic Regulatory Factors during developmental myogenesis
- 2.1 Somitic differentiation into sclerotome, dermomyotome, myotome and syndetome
- 2.2 MRFs control phases of developmental myogenesis
- 2.3 Viable mice can be generated after inactivation of Myf5, MyoD or MRF4, but not Myogenin
- 2.4 MYF5, MYOD and MRF4 overlap in directing myogenic specification, while Myogenin is indispensible for myogenic differen...
- 2.5 MRF-directed genetic cell ablation indicates that myoblasts express both Myf5 and MyoD
- 3 Role of the Myogenic Regulatory Factors in mature muscle
- 3.1 MRF4 is the most highly expressed MRF in healthy mature muscle
- 3.2 MYOD and Myogenin can influence MyHC content and metabolic properties of myofibres
- 3.3 MRF4 has a homeostatic role in repressing MEF2 to suppress hypertrophy
- 4 Myf5, MyoD and MRF4 are expressed during satellite cell specification
- 4.1 Satellite cells are derived from Pax3/Pax7 stem cells in trunk and limb
- 4.2 The Myf5, MyoD and Mrf4 loci are active during satellite cell specification
- 4.3 Satellite cell specification begins during embryogenesis
- 4.4 Individual MRFs are dispensable for satellite cell specification
- 5 Myf5 expression is maintained in quiescent satellite cells
- 5.1 Myf5 has been/is expressed in essentially all quiescent satellite cells
- 5.2 Does lack of Myf5 expression identify satellite ‘stem’ cells?
- 6 Myogenic Regulatory Factor function in satellite cells during regenerative myogenesis
- 6.1 All MRFs are re-expressed during regenerative myogenesis
- 6.2 MYF5 and MYOD control timely myogenic progression in satellite cells during regeneration
- 6.3 MRF expression dynamics in ex vivo models of regenerative myogenesis
- 6.4 MYF5 and MYOD are cell cycle regulated
- 6.5 MYF5 and MYOD control satellite cell proliferation
- 7 Summary
- 8 Future perspectives
- Competing financial interests
- Acknowledgements
- Appendix A Supplementary data
- References
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