| 标题： | Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells |
| 时间： | 2021-02-20 09:39:13 |
| DOI： | 10.1038/s41556-019-0299-0 |
| PMID： | 30936474 |
| 大小： | 4356 kb |
| 页数： | 21 PAGES |
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目录：
- Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of ...
- Results
- TAMs enhance aerobic glycolysis and inhibit apoptosis of breast cancer cells.
- TAMs enhance aerobic glycolysis and inhibit apoptosis of breast cancer cells by stabilizing HIF-1α protein.
- TAMs enhance aerobic glycolysis of breast cancer cells by EV-packaged lncRNA.
- HISLA transmitted by TAM EVs enhances aerobic glycolysis and induces apoptosis resistance in breast cancer cells.
- Lactate in the tumour microenvironment upregulates HISLA in TAMs.
- HISLA stabilizes HIF-1α by interfering in PHD2 and HIF-1α interactions.
- TAMs release HISLA in EVs to enhance glycolysis and chemoresistance of breast cancer in vivo.
- HISLA correlates with tumour glycolysis and chemoresistance of patients with breast cancer.
- Discussion
- Online content
- Acknowledgements
- Fig. 1 TAMs enhance aerobic glycolysis and inhibit apoptosis of breast cancer cells.
- Fig. 2 TAMs enhance aerobic glycolysis and inhibit apoptosis of breast cancer cells by stabilizing HIF-1α protein.
- Fig. 3 TAMs enhance the aerobic glycolysis of breast cancer cells by EV-packaged lncRNA.
- Fig. 4 HISLA transmitted by TAM EVs enhances aerobic glycolysis and induces apoptosis resistance in breast cancer cells.
- Fig. 5 Lactate in the tumour microenvironment upregulates HISLA in TAMs.
- Fig. 6 HISLA stabilizes HIF-1α by blocking PHD2 and HIF-1α interactions.
- Fig. 7 TAMs release HISLA in EVs to enhance glycolysis and induce chemoresistance in breast cancer in vivo.
- Fig. 8 HISLA correlates with tumour glycolysis and chemoresistance of patients with breast cancer.
- Results
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