在线客服: 点击这里给我发消息  新用户使用步骤:会员注册→充值→重新登入→进入资源
标题:Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells
时间:2021-02-20 09:39:13
DOI:10.1038/s41556-019-0299-0
PMID:30936474
大小:4356 kb
页数:21 PAGES
下载: 点击下载
预览:

浏览器不支持嵌入PDF阅读,打开新页面在线阅读

目录:
  • Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of ...
    • Results
      • TAMs enhance aerobic glycolysis and inhibit apoptosis of breast cancer cells.
      • TAMs enhance aerobic glycolysis and inhibit apoptosis of breast cancer cells by stabilizing HIF-1α protein.
      • TAMs enhance aerobic glycolysis of breast cancer cells by EV-packaged lncRNA.
      • HISLA transmitted by TAM EVs enhances aerobic glycolysis and induces apoptosis resistance in breast cancer cells.
      • Lactate in the tumour microenvironment upregulates HISLA in TAMs.
      • HISLA stabilizes HIF-1α by interfering in PHD2 and HIF-1α interactions.
      • TAMs release HISLA in EVs to enhance glycolysis and chemoresistance of breast cancer in vivo.
      • HISLA correlates with tumour glycolysis and chemoresistance of patients with breast cancer.
    • Discussion
    • Online content
    • Acknowledgements
    • Fig. 1 TAMs enhance aerobic glycolysis and inhibit apoptosis of breast cancer cells.
    • Fig. 2 TAMs enhance aerobic glycolysis and inhibit apoptosis of breast cancer cells by stabilizing HIF-1α protein.
    • Fig. 3 TAMs enhance the aerobic glycolysis of breast cancer cells by EV-packaged lncRNA.
    • Fig. 4 HISLA transmitted by TAM EVs enhances aerobic glycolysis and induces apoptosis resistance in breast cancer cells.
    • Fig. 5 Lactate in the tumour microenvironment upregulates HISLA in TAMs.
    • Fig. 6 HISLA stabilizes HIF-1α by blocking PHD2 and HIF-1α interactions.
    • Fig. 7 TAMs release HISLA in EVs to enhance glycolysis and induce chemoresistance in breast cancer in vivo.
    • Fig. 8 HISLA correlates with tumour glycolysis and chemoresistance of patients with breast cancer.

本页内容由网络收集而来,版权归原创者所有,如有侵权请及时联系