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标题:Encapsulation of moxifloxacin within poly(butyl cyanoacrylate) nanoparticles enhances efficacy against intracellular Mycobacterium tuberculosis
时间:2021-01-14 11:25:28
DOI:10.1016/j.ijpharm.2007.05.062
大小:589 kb
页数:10 PAGES
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目录:
  • Encapsulation of moxifloxacin within poly(butyl cyanoacrylate) nanoparticles enhances efficacy against intracellular Mycobacterium tuberculosis
    • Introduction
    • Materials and methods
      • Chemicals
      • Preparation and characterization of nanoparticles
        • Preparation of moxifloxacin-loaded PBCA nanoparticles
        • Characterization of moxifloxacin-loaded PBCA nanoparticles
        • Release of moxifloxacin from nanoparticles
        • Preparation of rhodamine B-loaded PBCA nanoparticles
      • Cell culture experiments
        • Macrophages
        • Determination of cytotoxicity of free MX, encapsulated MX, and empty nanoparticles in the macrophages
        • Test strain
        • Visualization of M. tuberculosis and nanoparticles in THP-1 cells
        • Measurement of MX accumulation in THP-1 cells
        • Bioassay for determination of MX concentration
        • Determination of nanoparticle-bound MX activity against intracellular M. tuberculosis
        • Data analysis
    • Results
      • Encapsulation of moxifloxacin in PBCA nanoparticles
      • Release of encapsulated moxifloxacin from PBCA nanoparticles
      • Effect of nanoparticle-encapsulated MX on the viability of cultured macrophages
      • Kinetics and degree of drug accumulation in macrophages
      • Accumulation of PBCA nanoparticles within macrophages
      • Effect of MX-loaded nanoparticles on M. tuberculosis within macrophages
    • Discussion
    • Conclusions
    • Acknowledgements
    • References

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