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标题:Memantine ameliorates tau protein deposition and secondary damage in the ipsilateral thalamus and sensory decline following focal cortical infarction in rats
时间:2021-01-13 20:00:25
DOI:10.1016/j.neulet.2020.135091
大小:7524 kb
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目录:
  • Memantine ameliorates tau protein deposition and secondary damage in the ipsilateral thalamus and sensory decline following focal cortical infarction in rats
    • Introduction
    • Materials and methods
      • Focal cortical infarction model
      • Memantine treatment
      • TTC staining
      • Adhesive removal test
      • Tissue preparation and nissl staining
      • Immunohistochemistry
      • Western blot
      • TUNEL staining
      • Image analysis and quantification
      • Statistical analysis
    • Results
      • Focal cortical infarction model
      • Memantine ameliorated sensory decline recovery after MCAO
      • Memantine alleviated secondary damage in the ipsilateral thalamus following MCAO
      • Memantine decreased the p-tau-231 deposits by decreasing PP2ApY307/GSK3βpY216 in the ipsilateral thalamus following MCAO
      • Memantine reduced apoptosis in the ipsilateral thalamus following MCAO
      • Correlation between sensory decline and thalamic p-tau-231 deposition or secondary thalamic damage
    • Discussion
    • Conclusion
    • Declaration of competing interest
    • Acknowledgements
    • References

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