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标题:Aldehyde dehydrogenase-positive melanoma stem cells in tumorigenesis, drug resistance and anti-neoplastic immunotherapy
时间:2021-01-11 10:39:06
DOI:10.1007/s11033-019-05227-2
PMID:31838656
大小:825 kb
页数:10 PAGES
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目录:
  • Aldehyde dehydrogenase-positive melanoma stem cells in tumorigenesis, drug resistance and anti-neoplastic immunotherapy
    • Abstract
    • Introduction
    • Melanoma stem cells determine tumor behavior and drug resistance
    • ALDH serve as an indicative and functional marker for MICs
      • Features of ALDH in normal SCs
      • Features of ALDH in melanoma CSCs
      • ALDH1A11A3 correlate with different phenotypes of MICs
    • ALDH drives resistance to chemotherapy in melanoma
      • Acquired resistance to chemotherapy in melanoma
      • Possible molecular mechanisms of development of drug resistance
      • ALDH activity regulates drug resistance in melanoma
    • Therapeutic potential based on ALDH+ melanoma CSCs
      • Efficacy of ALDH inhibitors as chemotherapeutic agents
      • Anti-melanoma singledoubletriple combination treatment based on CSC-DC vaccine
      • Autologous cytokine-induced killer cells target ALDH+ melanoma CSCs
      • Anti-B-cell lymphoma 2 (Bcl-2) family-mediated therapy inhibits ALDH+ CSCs
      • Targeting ALDHhigh CSCs through HhGlimo (GLI) pathway
      • Other potential therapies
    • Conclusion
    • Acknowledgements
    • References

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