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标题:Liraglutide Up-regulation Thioredoxin Attenuated Müller Cells Apoptosis in High Glucose by Regulating Oxidative Stress and Endoplasmic Reticulum Stress
时间:2020-11-22 21:59:17
DOI:10.1080/02713683.2020.1737137
PMID:32180468
大小:2154 kb
页数:11 PAGES
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目录:
  • Abstract
  • Introduction
  • Materials and methods
    • Cell culture and regents
    • Western blotting
    • Flow cytometry analysis
    • Immunofluorescence
    • Transfection
    • Measurement of intracellular ROS
    • Statistical analysis
  • Results
    • Effect of HG on Müller cells reactive gliosis and apoptosis
    • LIRA decreased HG-induced reactive gliosis and apoptosis in Müller cells
    • The protection of LIRA on HG-induced Müller cells apoptosis was through p-Erk/Nrf2/Trx pathway activation
    • LIRA activated p-Erk/Nrf2/Trx pathway regulated HG-induced ER stress in Müller cells
    • Trx plays akey role in the protective effect of LIRA on HG-induced apoptosis by regulating ER stress in Müller cells
  • Discussion
  • Conclusion
  • Acknowledgments
  • Funding
  • Declaration of interest
  • References

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