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标题:Neuroprotective Effects of Psalmotoxin-1, an Acid-Sensing Ion Channel (ASIC) Inhibitor, in Ischemia Reperfusion in Mouse Eyes
时间:2020-11-22 15:29:19
DOI:10.1080/02713683.2018.1454478
大小:2337 kb
页数:15 PAGES
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目录:
  • Abstract
  • Introduction
  • Material and methods
    • Animals
    • Ischemic–reperfusion injury with acute intraocular pressure elevation
    • Psalmotoxin-1 treatment for I/R
    • Pattern electroretinography (PERG)
    • Tissue processing
    • RGCs counts
    • Immunohistochemistry in retinal cryosections
    • Western blot
    • Statistical analyses of data
  • Results
    • Immunohistochemical analyses of ASIC1a and ASIC2 in retina following I/R injury
    • Psalmotoxin-1 increased survival of RBPMS-labeled retinal ganglion cells
    • Mechanism of I/R-induced RGC death involves calpain-1 activation, degradation of fodrin and HSP70, and abnormalities in antioxidant enzymes
  • Discussion
  • Acknowledgments
  • Funding
  • Author Contributions
  • References

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