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标题:Assessing the Pharmacological and Therapeutic Efficacy of Traditional Chinese Medicine Liangxue Tongyu Prescription for Intracerebral Hemorrhagic Stroke in Neurological Disease Models
时间:2020-11-22 13:50:24
DOI:10.3389/fphar.2018.01169
大小:1585 kb
页数:18 PAGES
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目录:
  • Assessing the Pharmacological and Therapeutic Efficacy of Traditional Chinese Medicine Liangxue Tongyu Prescription for Intracerebral Hemorrhagic Stroke in Neurological Disease Models
    • Introduction
    • Materials And Methods
      • ICH Associated Genes
      • All Compounds in LP
      • The Properties of Compounds in LP
      • Predicting Target Profiles of Compounds in LP
      • Oral Bioavailability and Drug-Likeness Screening
      • Systems Pharmacology Network Construction and Analysis
      • Experimental Validation
        • Materials
        • Extraction Preparation
        • Durgs and Reagents
        • Animals and Prescription Administration
        • Cells Culture and Treatment
        • Cell Counting Kit-8 Assay
        • Flow Cytometry (FCM) With Propidium Iodide (PI) Staining
        • Real-Time Quantitative Polymerase Chain Reaction
        • Western Blotting
      • Statistical Analysis
    • Results
      • Excavation of Compounds Database of LP and Targets Database on ICH
      • Network Analysis of Compounds in LP on ICH
      • Network and Pathway Analysis of Potential Compounds in LP on ICH
        • Potential Compounds in LP Screening
        • Network Analysis of Potential Compounds in LTF on ICH
        • Pathway Analysis of Targets Associated With Potential Compounds in LP on ICH
      • Experimental Verification on ICH
        • Pharmacodynamic Evaluation of LP on SHR Model
        • Effects of Extracted Fractions and Compounds of LP on L-Glutamate-Induced PC12 Cell Proliferation
        • Effects of Extract of LP and Its Extracted Fractions on L-Glutamate-Induced PC12 Cell Apoptosis
      • Effect of Compound Combination in LP
        • Properties Analysis of Total Compounds in LP
        • Effects of Compound Combination in LP on L-Glutamate-Induced PC12 Cell Proliferation
        • Effects of Compound Combination on L-Glutamate-Induced PC12 Cell Apoptosis
        • Effects of Compounds and Their Combination in LP on PI3K/AKT Pathway
    • Discussion
    • Ethics Statement
    • Author Contributions
    • Funding
    • References

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