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标题:Differential mRNA expression combined with network pharmacology reveals network effects of Liangxue Tongyu Prescription for acute intracerebral hemorrhagic rats
时间:2020-11-22 13:44:43
DOI:10.1016/j.jep.2019.112231
大小:1923 kb
页数:12 PAGES
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目录:
  • Differential mRNA expression combined with network pharmacology reveals network effects of Liangxue Tongyu Prescription for acute intracerebral hemorrhagic rats
    • Introduction
    • Materials and methods
      • Experimental animals
      • Drug preparation
      • Reagents
      • Methods of randomization
      • Preparation of AICHs model
      • Intervention method of LTP experiment
      • mRNA-sequencing experimental methods
      • Experimental effect
        • Survival time and survival rate
        • Determination of differentially mRNA transcriptomes
      • Statistical analysis method
        • Data analysis of dosage of collagenase and LTP experiment
        • RNA-seq data analysis
      • Construction and verification of pharmacology network model
    • Results
      • Survival analysis of rat model of AICH induced by different doses of collagenase
      • Survival analysis of the effect of LTP on AICHs
      • The network effect mechanism of LTP in the treatment of AICHs
        • Differential gene expression profiles of LTP in the treatment of AICHs
        • Reconstruction and verification of LTP effect network based on pharmacodynamic difference gene for AICH
        • Validating compound-target network model
      • Validating compound-target-pathogenesis(disease) network model
    • Discussion
      • Survival analysis of LTP efficacy on AICHs
      • Network pharmacology study of LTP efficacy
    • Conclusion
    • Data availability statement
    • Author contributions
    • Funding
    • Conflicts of interest
    • Ethics statement
    • Acknowledgments
    • Abbreviations
    • Supplementary data
    • References

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