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标题:Assessment of preclinical drug interactions of bedaquiline by a highly sensitive LC-ESI-MS/MS based bioanalytical method
时间:2020-11-22 00:12:22
DOI:10.1016/j.jchromb.2019.02.022
大小:1502 kb
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目录:
  • Assessment of preclinical drug interactions of bedaquiline by a highly sensitive LC-ESI-MS/MS based bioanalytical method
    • Introduction
    • Materials and methods
      • Chemicals and reagents
      • Instrumentation and LC-MS/MS conditions
      • Preparation of stock, standard and quality control samples
      • Sample preparation
      • Method validation
      • Assessment of preclinical drug-drug interactions
        • Animal husbandry, maintenance, and ethical prerequisite
        • Dose selection and preparation
        • Study design
        • Blood sampling, processing, and data analysis
        • Statistical analysis
    • Results and discussion
      • Optimization of LC-MS/MS conditions
      • Optimization of extraction solvent
      • Optimization of internal standard
      • Method validation
        • Specificity
        • Linearity and LLOQ
        • Accuracy and precision
        • Recovery
        • Matrix effect
        • Stability
        • Carryover
        • Dilution integrity
      • Assessment of preclinical drug-drug interactions
    • Conclusions
    • Acknowledgements
    • Conflict of interest
    • References

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