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标题:Nuclear translocation of phosphorylated STAT3 regulates VEGF-A-induced lymphatic endothelial cell migration and tube formation
时间:2020-11-21 23:52:41
DOI:10.1016/j.bbrc.2011.07.111
大小:868 kb
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目录:
  • Nuclear translocation of phosphorylated STAT3 regulates VEGF-A-induced lymphatic endothelial cell migration and tube formation
    • 1 Introduction
    • 2 Materials and methods
      • 2.1 LEC culture
      • 2.2 Western blot analysis
      • 2.3 Migration assay
      • 2.4 Matrigel tube formation assay
      • 2.5 Adenovirus vector (Ax)
      • 2.6 Statistical analysis
    • 3 Results
      • 3.1 VEGF-A induces LEC migration and tube formation
      • 3.2 VEGF-A translocates phosphorylated STAT3 (p-STAT3) to the nucleus in LECs
      • 3.3 STAT3F inhibits VEGF-induced nuclear translocation of p-STAT3
      • 3.4 STAT3F inhibits VEGF-A-induced LEC migration and tube formation
    • 4 Discussion
    • Acknowledgments
    • References

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