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时间:2020-11-20 15:25:09
DOI:10.1080/02713683.2019.1633359
大小:2657 kb
页数:14 PAGES
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目录:
  • Abstract
  • Introduction
  • Methods and materials
    • Animals
    • Drugs and reagents
    • Selenite-induced cataracts and trimetazidine injection
    • Cell culture
    • Viability and apoptosis assays in HLEB3 cells
    • Intracellular ROS staining
    • DNA fragmentation
    • Activities of antioxidant enzymes
    • Western blotting
    • Bisulfite DNA sequencing
    • Statistical analysis
  • Results
    • Effect of TMZ on lens opacification
    • Selenite-induced apoptosis and ROS could be relieved by TMZ
    • TMZ-mediated anti-oxidant effect retarding the apoptosis process was modulated by the keap1/Nrf2-are signalling pathway
    • TMZ inhibited the methylation of CpGs in the promoter region of keap1
  • Discussion
  • Conclusions
  • Acknowledgments
  • Author Contributions
  • Declaration of interest
  • Funding
  • References

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