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标题:NT5DC2 suppression restrains progression towards metastasis of non-small-cell lung cancer through regulation p53 signaling
时间:2020-11-20 12:29:22
DOI:10.1016/j.bbrc.2020.06.139
PMID:32962856
大小:3040 kb
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目录:
  • NT5DC2 suppression restrains progression towards metastasis of non-small-cell lung cancer through regulation p53 signaling
    • 1. Introduction
    • 2. Materials and methods
      • 2.1. Cells and culture
      • 2.2. Flow cytometry analysis
      • 2.3. RT-qPCR
      • 2.4. Western blotting
      • 2.5. Transwell analysis
      • 2.6. TUNEL staining in cells
      • 2.7. Animals and treatments
        • 2.7.1. Tumor growth calculation
        • 2.7.2. Liver metastasis analysis
      • 2.8. Immunohistological staining
      • 2.9. Statistical analysis
    • 3. Results
      • 3.1. NT5DC2 expression is increased in NSCLC tissues and cell lines
      • 3.2. NT5DC2 promotes proliferation, migration and invasion in NSCLC cells
      • 3.3. NT5DC2 suppression induces G2/M cell cycle arrest and apoptosis in NSCLC cells
      • 3.4. NT5DC2-regulated proliferation and apoptosis is p53-dependent in NSCLC cells
    • 4. Discussion
    • Transparency document
    • Appendix A. Supplementary data
    • References

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