在线客服: 点击这里给我发消息  新用户使用步骤:会员注册→充值→重新登入→进入资源
标题:An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
时间:2020-10-28 16:30:23
DOI:10.1038/s41593-019-0501-5
PMID:31591557
大小:1955 kb
页数:19 PAGES
下载: 点击下载
预览:

浏览器不支持嵌入PDF阅读,打开新页面在线阅读

目录:
  • An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological association ...
    • Results
      • Study design.
      • Discovery analysis to identify AD differentially expressed circRNAs.
      • Replication and meta-analysis of circRNA differential expression using an independent AD dataset.
      • AD-associated changes in circRNA expression demonstrate independence from AD-associated changes in their cognate linear mRN ...
      • AD-associated changes in circRNA expression are consistent across cortical regions.
      • Evidence supporting circRNA differential expression in pre-symptomatic AD.
      • Changes in circRNA expression are more severe in individuals with autosomal dominant AD.
      • AD-associated circRNAs explain more of the variation in AD quantitative measures than number of APOE4 alleles or estimated ...
      • Differentially expressed circRNAs co-express with AD-relevant genes and pathways.
      • AD-associated circRNAs contain binding sites for miRNAs that potentially regulate AD-associated pathways and genes.
    • Discussion
      • Ethics approval and consent to participate.
      • Accession codes.
    • Online content
    • Acknowledgements
    • Fig. 1 Cortical circRNAs are associated with AD traits.
    • Fig. 2 Changes in cortical circRNA expression tracks with AD clinical severity.
    • Fig. 3 AD-associated circRNAs explain more of the observed variation in clinical dementia rating compared with number of APOE4 alleles or the estimated proportion of neurons.
    • Fig. 4 AD-associated circRNAs co-express with AD-relevant genes.
    • Table 1 Cortical circRNAs are significantly associated with AD case status, dementia severity and neuropathological severity.

本页内容由网络收集而来,版权归原创者所有,如有侵权请及时联系