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时间:2020-10-27 23:00:06
DOI:10.1007/978-1-4419-7130-2_26
大小:256 kb
页数:12 PAGES
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目录:
  • Cardiorenal Protection in Diabetes Mellitus
    • Introduction
    • High-Glucose-Induced PKC Translocation
    • PKC-ε-Dependent Survival Signals in Diabetic Hearts
    • PKCε Cardioprotection
    • Stress-Induced miRNA and Cardiac Phenotype
    • Inhibition of p66ShcA Redox Activity Attenuates Hyperglycemia-Induced Oxidative Stress and Apoptosis
    • Redox Function of WTp66ShcA Protein
    • Diabetes Accumulates ROS
    • Mesangial Cell Apoptosis by Oxidant-Dependent Mechanism
    • IGF-1 Inhibits the Mitochondrial Apoptosis Program in Mesangial Cells
    • IGF-1R Inhibits Hyperglycemia-Induced DNA Damage and Promotes DNA Repair
    • p66ShcA Prevents Glycooxidant-Dependent FOXO3a Regulation
    • Conclusions
    • References

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