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标题:Lipidoid Tail Structure Strongly Influences siRNA Delivery Activity
时间:2020-10-27 19:00:35
DOI:10.1007/s12195-016-0436-9
大小:1605 kb
页数:11 PAGES
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目录:
  • Lipidoid Tail Structure Strongly Influences siRNA Delivery Activity
    • Abstract
    • Introduction
    • Materials and Methods
      • Lipidoid Synthesis
      • Formulation and Characterization of Lipidoid-siRNA Nanoparticles
      • In Vitro siRNA Transfection
      • Measurement of LNP’s pKa
      • Factor VII Silencing In Vivo
      • In Vivo Imaging Studies
    • Results and Discussion
      • A Lipidoid Library was Synthesized From Alkyl-Amines and Acrylate-Tails
      • LNP pKa Values Influenced Nanoparticle Silencing Efficiency
      • 306Oi10 LNPs Effectively Silenced Factor VII In Vivo
      • 306Oi10 LNPs Accumulate Predominantly in the Liver
    • Conclusion
    • Conclusion
    • References

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