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标题:GSK3 inhibitor-loaded osteotropic Pluronic hydrogel effectively mitigates periodontal tissue damage associated with experimental periodontitis
时间:2020-10-18 21:48:06
DOI:10.1016/j.biomaterials.2020.120293
大小:10274 kb
页数:14 PAGES
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目录:
  • GSK3 inhibitor-loaded osteotropic Pluronic hydrogel effectively mitigates periodontal tissue damage associated with experim ...
    • 1 Introduction
    • 2 Methods and materials
      • 2.1 Materials and reagents
      • 2.2 Synthesis of pyrophosphorylated Pluronic F127 (F127-PPi)
        • 2.2.1 Synthesis of tosylated Pluronic F127
        • 2.2.2 Synthesis of pyrophosphorylated Pluronic F127
      • 2.3 Preparation of BIO-loaded thermoresponsive hydrogel
      • 2.4 Binding potential to model bone (hydroxyapatite, or HA)
      • 2.5 Evaluation of BIO’s solubility in PF127 and F127 solutions
      • 2.6 In vitro release of BIO from hydrogel
      • 2.7 In vitro hydrogel erosion
      • 2.8 Biocompatibility of PF127 hydrogel
      • 2.9 Gelation and viscosity studies
      • 2.10 The therapeutic efficacy of BIO-containing hydrogels on a rat model of experimental periodontitis
      • 2.11 Micro-computed Tomography (μ-CT) analysis of periodontal bone
      • 2.12 Histological analysis
      • 2.13 Statistical analysis
    • 3 Results
      • 3.1 Hydrogel binding to hydroxyapatite (HA)
      • 3.2 Solubility of BIO in PF127 vs F127
      • 3.3 In vitro release of BIO from PF127 hydrogel
      • 3.4 In vitro hydrogel erosion
      • 3.5 Biocompatibility of PF127-based hydrogel
      • 3.6 Gelation and viscosity analysis of PF127 hydrogel
      • 3.7 Micro-computed tomography (μ-CT) analysis of the periodontal bone
      • 3.8 Histological evaluation
    • 4 Discussion
    • 5 Conclusion
    • CRediT authorship contribution statement
    • Declaration of Competing Interest
    • Acknowledgment
    • Appendix A Supplementary data
    • Data availability
    • References

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