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标题:Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand
时间:2020-10-18 21:45:46
DOI:10.1016/j.biomaterials.2020.120355
大小:5896 kb
页数:22 PAGES
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目录:
  • Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand
    • 1 Introduction
    • 2 Structural and biological properties
      • 2.1 Molecular structure
      • 2.2 Iron binding
      • 2.3 Tertiary structure & glycosylation
      • 2.4 Receptors
      • 2.5 Absorption & oral bioavailability
      • 2.6 Half-life and metabolism
    • 3 Pharmacological activities of lactoferrin
      • 3.1 Iron homeostasis
      • 3.2 Antimicrobial activity
        • 3.2.1 Anti-bacterial activity
        • 3.2.2 Antiviral activity
        • 3.2.3 Antiparasitic and antifungal activity
      • 3.3 Anticarcinogenic activity
      • 3.4 Wound healing
    • 4 Delivery of lactoferrin as active therapeutic
      • 4.1 Microparticles
      • 4.2 Nanoparticles
      • 4.3 Liposomes
      • 4.4 PEGylation
    • 5 Preparation techniques of lactoferrin nanocarriers
      • 5.1 Sol-in-oil emulsion
      • 5.2 Desolvation
      • 5.3 Thermal denaturation
      • 5.4 Albumin-bound nanoparticle (Nab) technology
      • 5.5 Electrostatic nanocomplexes
      • 5.6 Lactoferrin-drug nanoconjugates
      • 5.7 Amphiphilic micelles
      • 5.8 Lactoferrin shell-oily core nanocapsules
      • 5.9 Lactoferrin-inorganic nanocomposites
    • 6 Design of Lf-targeted nanocarriers
    • 7 Pharmaceutical applications
      • 7.1 Brain delivery
        • 7.1.1 Brain tumors
        • 7.1.2 Parkinson disease (PD)
        • 7.1.3 Alzheimer
      • 7.2 Colon cancer targeting
      • 7.3 Liver cancer targeting
      • 7.4 Breast cancer targeting
      • 7.5 Lung cancer targeting
      • 7.6 Prostate cancer targeting
      • 7.7 Cancer theranostics
      • 7.8 Nuclear targeting
      • 7.9 Immunomodulatory applications
      • 7.10 Antiviral drug delivery
      • 7.11 Bone engineering
    • 8 Challenges and limitations
    • 9 Clinical trials & future perspectives
    • Declaration of competing interest
    • Appendix A Supplementary data
    • References

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