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标题:Preclinical In Vitro and In Vivo Characterization of Synaptic Vesicle 2A–Targeting Compounds Amenable to F-18 Labeling as Potential PET Radioligands for Imaging of Synapse Integrity
时间:2020-10-17 23:02:10
DOI:10.1007/s11307-019-01428-0
大小:2077 kb
页数:11 PAGES
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目录:
  • Labeling as Potential PET Radioligands for Imaging of Synapse Integrity
    • Abstract
    • Introduction
    • Materials and Methods
      • Compounds
      • Radiochemistry
      • Homogenate Preparation
      • In’Vitro Homogenate Binding
      • Autoradiography
      • In’Vivo Imaging in Rat Using micro-PET
    • Results
      • Homogenate Binding Studies
        • Optimizing the Binding Protocol to Screen Novel SV2A Ligands
        • Screening of Novel Potential F-18-Labeled SV2A Ligands
      • Autoradiography
        • Distribution of Specific [3H]UCB-J (1&newnbsp;nM) Binding in Mammalian Brain
        • Comparison of Healthy Control and AD Sections Using a Wash and No-Wash Characterization
        • Dynamic Micro-PET Imaging in Rat Brain Using [18F]MNI-1126/[18F]SDM-8
    • Discussion
    • Conclusions
    • Compliance with Ethical Standards
    • References

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