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标题:[11C]UCB-A, a novel PET tracer for synaptic vesicle protein 2A
时间:2020-10-17 22:24:56
DOI:10.1016/j.nucmedbio.2016.03.004
大小:827 kb
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目录:
  • [11C]UCB-„A, a novel PET tracer for synaptic vesicle protein „2A
    • 1. Introduction
    • 2. Material and methods
      • 2.1. Chemistry
        • 2.1.1. Equipment
        • 2.1.2. Synthesis and purification of [11C]UCB-A
        • 2.1.3. Metabolite analysis
      • 2.2. Rat studies
        • 2.2.1. Frozen section autoradiography
        • 2.2.2. Biodistribution and dosimetry
        • 2.2.3. PET binding study
      • 2.3. Pig studies
        • 2.3.1. Scan protocol
        • 2.3.2. Blood data
        • 2.3.3. Data analysis
        • 2.3.4. Animal Welfare
    • 3. Results
      • 3.1. Chemistry
        • 3.1.1. Synthesis of [11C]UCB-A
        • 3.1.2. Metabolite analysis
      • 3.2. Rat studies
        • 3.2.1. Frozen section autoradiography
        • 3.2.2. Biodistribution and dosimetry
        • 3.2.3. PET binding study
      • 3.3. Pig study
    • 4. Discussion
    • 5. Conclusions
    • Acknowledgements
    • References

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