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标题:Acquisition of Cholangiocarcinoma Traits during Advanced Hepatocellular Carcinoma Development in Mice
时间:2020-10-17 22:13:39
DOI:10.1016/j.ajpath.2017.11.013
大小:6000 kb
页数:17 PAGES
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目录:
  • Acquisition of Cholangiocarcinoma Traits during Advanced Hepatocellular Carcinoma Development in Mice
    • Materials and Methods
      • Mice
      • Liver Organoid Culture
      • Ultrasound-Guided Intrahepatic Cell Injection
      • Quantification of Tumor Burden in LCO Recipient Mice
      • Antibodies
      • RNA Sequencing
      • Extracellular Vesicle Analysis by Mass Spectrometry
      • Unsupervised Gene Hierarchical Clustering, Principal Component Analysis, GSEA, and Gene Ontology Enrichment Analysis
      • KEGG Pathway Enrichment Analysis and Visualization
    • Results
      • Spontaneous HG Tumors in PPTR Mice Display Human Liver Cancer Gene Signatures Associated with Poor Prognosis and CC-Like Traits
      • 3D Stem Cell Cultures Enable Rapid Propagation of Primary LCOs with Stem Cell Characteristics from Nonmetastatic PPTR Prima ...
      • LCOs from Primary Mouse HCC Generate Widespread Invasion and Metastases on Orthotopic Transplantation
      • LCO-Driven Tumors Molecularly Recapitulate the Spontaneous Metastases of PPTR Mice
      • LCO-Driven Tumors Display Combined Hepatocellular and Cholangiocarcinoma Histopathology
      • 3D Stem Cell Culture Does Not Induce Cholangiocyte Differentiation in LCOs Generated from Mouse Primary HB
      • Extracellular Vesicle Proteins Are Increased in the Plasma of Mice Bearing LCO-Driven HG Tumors
    • Discussion
    • Conclusions
    • Acknowledgments
    • Supplemental Data
    • References

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