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标题:Liver regeneration: biological and pathological mechanisms and implications
时间:2020-09-12 16:59:19
DOI:10.1038/s41575-020-0342-4
PMID:32764740
大小:1539 kb
页数:17 PAGES
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目录:
  • Liver regeneration: biological and pathological mechanisms and implications
    • Regeneration after partial hepatectomy
      • Immediate events after partial hepatectomy
      • Early events after partial hepatectomy
    • Regenerative activities of hepatocytes
      • Intracellular events
      • Extracellular signalling factors
        • Signals regulating liver regeneration and hepatocyte proliferation
        • Receptor tyrosine kinases and their ligands
        • Auxiliary mitogenic signals
        • Complex mitogenic pathways
    • Regeneration in other hepatic cells
      • Cholangiocytes
      • Liver sinusoidal endothelial cells
      • Kupffer cells and immune cells
      • Hepatic stellate cells
    • Termination of liver regeneration
    • Alternative regenerative pathways
    • Drug-​induced liver injury
    • Regeneration in recolonization
    • Liver ‘stem cells’?
    • Cell proliferation activities in normal liver
    • Clinical implications
    • Conclusions
    • Fig. 1 Multiple signalling molecules regulate cell proliferation during liver regeneration.
    • Fig. 2 Extracellular signals involved in liver regeneration are classified according to their actions on hepatocytes and their overall effect on liver regeneration.
    • Fig. 3 Transdifferentiation events between hepatocytes and cholangiocytes.

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