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标题:Mechanism of Candida pathogenesis: revisiting the vital drivers
时间:2020-09-12 09:40:14
DOI:10.1007/s10096-020-03912-w
PMID:32372128
大小:1289 kb
页数:24 PAGES
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目录:
  • Mechanism of Candida pathogenesis: revisiting the vital drivers
    • Abstract
    • Introduction
    • Review methodology
    • Pathogenicity of Candida species
    • Host response to Candida species
    • Determinants of pathogenesis/virulent factors
      • Hyphae formation mediated by morphology-associated genes/transcription factors
      • Phenotypic switching
      • Biofilm formation
      • Metabolic flexibility/nutritional factors
      • Synergistic coaggregation with resident microbiota
      • Extracellular hydrolytic enzymes and proteins
        • Hemolysins
        • Phospholipases
        • Proteinases
        • Lipases
        • Coagulase
      • Secretion of cytolytic proteins (candidalysins)
      • Heat shock protein secretion
      • Adaptation to pH fluctuation
      • Efficient responses to multiple stresses
      • Genome plasticity
      • Adherence to surfaces
      • Antifungal resistance
    • Conclusion/recommendation
    • References

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