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标题:Pharmacological Therapies for Machado-Joseph Disease
时间:2020-08-01 18:43:53
DOI:10.1007/978-3-319-71779-1_19
大小:385 kb
页数:27 PAGES
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目录:
  • 19 Pharmacological Therapies for Machado-Joseph Disease
    • Abstract
    • 19.1 Machado-Joseph Disease or Spinocerebellar Ataxia Type 3
    • 19.2 Symptomatic Therapies for Machado-Joseph Disease
    • 19.3 Disease-Modifying Therapies for Machado-Joseph Disease: Lessons from Preclinical Trials
      • 19.3.1 Mutant Ataxin-3 Refolding and Degradation: Autophagy and Proteasome Inducers
      • 19.3.2 Therapies Targeting Downstream Molecular Events
        • 19.3.2.1 Transcriptional Regulation
        • 19.3.2.2 Calcium Signaling Stabilizers
        • 19.3.2.3 Neuroprotection
        • 19.3.2.4 Modulators of the Serotonergic and Glutamatergic Systems
    • 19.4 Clinical Trials in MJD Patients
    • 19.5 Concluding Remarks
    • References

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