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标题:Reverse genetics approaches for the development of bunyavirus vaccines
时间:2020-07-07 17:51:17
DOI:10.1016/j.coviro.2020.05.004
大小:972 kb
页数:11 PAGES
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目录:
  • Reverse genetics approaches for the development of bunyavirus vaccines
    • Introduction
    • Bunyavirus genome organization
    • Bunyavirus reverse genetics systems
      • Investigation of Bunyavirus virulence factors using reverse genetics
    • Immune correlates of protection against bunyaviruses
    • Bunyavirus reverse genetics approaches for live-attenuated vaccine candidates
      • Vaccine candidates carrying mutations or deletions in specific viral genes
      • Codon-deoptimization of viral genes
      • Single-cycle replicable vaccine candidates
      • Viral genome rearrangement
      • Vaccine candidates with chimeric viral genes
    • Conclusions and future perspectives
    • Conflict of interest statement
    • References and recommended reading
    • Acknowledgements

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