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标题:Gefitinib enhances human colon cancer cells to TRAIL-induced apoptosis of via autophagy- and JNK-mediated death receptors upregulation
时间:2020-07-01 12:12:25
DOI:10.1007/s10495-016-1287-5
大小:8726 kb
页数:12 PAGES
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目录:
  • Gefitinib enhances human colon cancer cells to TRAIL-induced apoptosis of via autophagy- and JNK-mediated death receptors upregulation
    • Abstract
    • Introduction
    • Materials and methods
      • Reagents
      • Cell lines and cell culture
      • WST-1 assay
      • Annexin V-FITC/PI flow cytometric analysis
      • Propidium iodide (PI) staining for DNA fragmentation
      • Reverse transcription polymerase chain reaction (RT-PCR)
      • Flow cytometric analysis of the expression of cell surface DR4 and DR5
      • Transfection with siRNA
      • Western blotting
      • Statistical analysis
    • Results
      • Gefitinib enhances TRAIL-induced apoptosis in HCT116 cells
      • Additive effect of gefitinib and TRAIL on TRAIL-resistant HT-29 cells
      • Cell surface death receptor induction by gefitinib is required for the synergistic effect
      • Gefitinib-induced death receptors upregulation is mediated by autophagy
      • Gefitinib-induced death receptors expression via JNK activation
    • Discussion
    • References

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