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标题:Utility of Ruxolitinib in a Child with Chronic Mucocutaneous Candidiasis Caused by a Novel STAT1 Gain-of-Function Mutation
时间:2020-06-27 07:21:28
DOI:10.1007/s10875-018-0519-6
PMID:29934865
大小:5223 kb
页数:14 PAGES
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目录:
  • Utility of Ruxolitinib in a Child with Chronic Mucocutaneous Candidiasis Caused by a Novel STAT1 Gain-of-Function Mutation
    • Abstract
    • Abstract
    • Abstract
    • Abstract
    • Abstract
    • Introduction
    • Methods
      • STAT1 Sequencing
      • Immunophenotyping
      • CD4+ Subset Analysis (IL-17+Th, IFNγ+Th, Tregs)
      • Western Blotting
      • Phospho-Flow
      • Gene Expression by qRT-PCR
      • Intracellular Cytokine Detection
    • Results
      • Case Report
      • Detection of STAT1 Mutation
      • STAT Phosphorylation Dynamics
      • STAT1/STAT3-Dependent/Th17-Related Gene Transcription Alteration
      • Lymphocyte Subpopulation Profile
      • Cytokine Production
    • Discussion
    • Conclusion
    • References

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