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标题:Mechano-therapeutics: Targeting Mechanical Signaling in Fibrosis and Tumor Stroma
时间:2020-05-23 21:49:40
DOI:10.1016/j.pharmthera.2020.107575
大小:1602 kb
页数:14 PAGES
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目录:
  • Mechano-„therapeutics: Targeting Mechanical Signaling in Fibrosis and Tumor Stroma
    • 1. Introduction
    • 2. Mechanobiology of tissue repair and organ fibrosis
    • 3. Targeting matrix crosslinking and stiffening in fibrotic disease
    • 4. Targeting mechanobiology of myofibroblasts in fibrotic disease
    • 5. Targeting mechanical control of TGF-β1 activation
    • 6. Mechanobiology in the Tumor Stroma
    • 7. Targeting matrix and mechanical contributions to tumor progression
    • 8. Targeting mechanobiology of cancer-associated fibroblasts
      • 8.1. YAP/TAZ, MRTF and ROCK
      • 8.2. JAK/STAT
      • 8.3. Epigenetic targets
      • 8.4. Hedgehog
      • 8.5. Anti-fibrotics
    • 9. Targeting Integrin-mediated TGF-β1 activation in CAFs
    • 10. Concluding remarks
    • Declaration of Competing Interest
    • Acknowledgements
    • Author contributions
    • References

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