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标题:IRF3 enhances NF-κB activation by targeting IκBα for degradation in teleost fish
时间:2020-05-23 17:21:53
DOI:10.1016/j.dci.2020.103632
PMID:31987876
大小:1262 kb
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目录:
  • IRF3 enhances NF-κB activation by targeting IκBα for degradation in teleost fish
    • Introduction
    • Materials and methods
      • Plasmids construction
      • Cell culture and transient transfections
      • Luciferase reporter assays
      • Immunoblot assays
      • Immunoprecipitation assay
      • Statistical analysis
    • Results
      • IRF3 attenuates the inhibitory effect of IκBα on NF-κB activation
      • IRF3 promotes IκBα degradation
      • Knockdown of IRF3 relieve IκBα degradation
      • IRF3 promotes IκBα degradation through proteasome pathway
      • IRF3 leads to elevation of IκBα polyubiquitination and shortens its half-life
    • Discussion
    • Acknowledgments
    • Supplementary data
    • References

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