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标题:Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic?
时间:2020-05-22 21:16:20
DOI:10.1016/j.jmb.2015.10.029
PMID:26562506
大小:1656 kb
页数:15 PAGES
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目录:
  • Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyl...
    • Introduction
    • Results
      • Mutations influence protein structure and stability in solution
      • Mutations influence protein–lipid interactions
      • Mutations influence local conformation and dynamics in the helix bundle
      • Central linker holds clues to non-amyloidogenic behavior of L159R
      • Effects of mutations on the EX1/EX2 exchange kinetics
      • Propagation of conformational changes to distant sites
    • Discussion
      • Summary of the mutational effects on the conformation of free apoA-I
      • What makes the protein amyloidogenic?
    • Materials and Methods
    • Acknowledgements
    • Appendix A. Supplementary data
    • References

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