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标题:Immune crosstalk in cancer progression and metastatic spread: a complex conversation.
时间:2020-03-26 23:56:15
DOI:10.1038/s41577-019-0271-z
PMID:32024984
大小:2131 kb
页数:16 PAGES
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目录:
  • Immune crosstalk in cancer progression and metastatic spread: a complex conversation
    • Modelling metastatic disease in vivo
    • The metastatic cascade and the premetastatic niche
    • Cancer cell–immune cell crosstalk
    • Chronic inflammation and cancer progression
    • Intratumoural immune cell crosstalk
      • Subversion of T cell priming to enable metastasis
      • T cell infiltration and exclusion
      • Suppression of T cell effector functions
        • Immunosuppression by monocytes
        • MDSCs: a heterogeneous population of myeloid cells with immunosuppressive capacities
        • Role of tumour-associated macrophages
        • Macrophage and neutrophil activation and polarization
        • Intratumoural roles of neutrophils
        • Immunosuppression by regulatory T cells
        • Immunosuppression via B cell crosstalk
    • Systemic inflammation, enabling metastasis
      • Tumour-​induced haematopoietic changes
      • Systemic myeloid expansion
      • The IL-1–IL-17–G-CSF axis
      • The CCL2–CCR2 axis
    • Conclusions and perspectives
    • Acknowledgements
    • Fig. 1 T cell priming to tumour antigens and subversion of this process.
    • Fig. 2 The immunosuppressive tumour microenvironment.
    • Fig. 3 Systemic inflammation, enabling metastasis.

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