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标题:A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir.
时间:2020-03-26 20:39:16
DOI:10.1038/clpt.2009.253
PMID:20147896
作者:Dumond, J B;Vourvahis, M;Rezk, N L
关键词:tetrahydropalmatine;chiral;protein-binding;stereoselectivity;HSA;AGP
摘要:http://www.nature.com/doifinder/10.1038/clpt.2009.253
大小:400 kb
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目录:
  • A Phenotype-Genotype Approach to Predicting CYP450 and P-Glycoprotein Drug Interactions
    • Abstract
    • Results
      • Baseline characteristics
      • Pharmacokinetic/pharmacogenomic analysis
        • CYP1A2, NAT-2, and XO activity
        • CYP2C9 activity
        • CYP2C19 activity
        • CYP2D6 activity.
        • Hepatic and intestinal CYP3A enzyme activity.
        • Hepatic and intestinal P-gp activity
    • Discussion
    • Methods
      • Outline placeholder
        • Subjects
        • Study design
        • Analytical methods
        • Data and statistical analysis
    • SUPPLEMENTARY MATERIAL
    • Acknowledgments
    • Conflict of Interest
    • References

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