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标题:Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics.
时间:2020-03-26 20:23:50
DOI:10.1007/7854_2015_5003
PMID:27305922
作者:Tatiana M Kazdoba;Prescott T Leach;Mu Yang
关键词:Autism;Mice;Rats;Genes;Mutant models;Social behavior;Sociability;Repetitive behavior;Cognition;Ultrasonic vocalization
出版源: 《Current Topics in Behavioral Neurosciences》 ,2016 ,28
摘要:Animal models provide preclinical tools to investigate the causal role of genetic mutations and environmental factors in the etiology of autism spectrum disorder (ASD). Knockout and humanized knock-in mice, and more recently knockout rats, have been generated for many of the de novo single gene mutations and copy number variants (CNVs) detected in ASD and comorbid neurodevelopmental disorders. Mouse models incorporating genetic and environmental manipulations have been employed for preclinical testing of hypothesis-driven pharmacological targets, to begin to develop treatments for the diagnostic and associated symptoms of autism. In this review, we summarize rodent behavioral assays relevant to the core features of autism, preclinical and clinical evaluations of pharmacological interventions, and strategies to improve the translational value of rodent models of autism.
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页数:53 PAGES
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目录:
  • 5003 Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics
    • Abstract
    • 1 Introduction
    • 2 Animal Models to Understand the Causes of Autism
    • 3 Mouse Behavioral Assays Relevant to the Diagnostic and Associated Symptoms of Autism
      • 3.1 Social Tests
      • 3.2 Social Communication
      • 3.3 Motor Stereotypies, Repetitive Behaviors, and Restricted Interests
      • 3.4 Associated Symptoms
    • 4 Evaluating Pharmacological Therapeutics in Animal Models with High Construct Validity and Strong Face Validity for ASD
    • 5 Conclusions
    • Acknowledgments
    • References

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