在线客服: 点击这里给我发消息  新用户使用步骤:会员注册→充值→重新登入→进入资源
标题:Comparison of intralesional verapamil with intralesional triamcinolone in the treatment of hypertrophic scars and keloids.
时间:2020-03-26 20:16:17
DOI:10.4103/0378-6323.42899
PMID:18797054
作者:Margaret FX Shanthi;Ernest Kalpana;Dhanraj Prema
关键词:Hypertrophic scar;Keloid;Triamcinolone;Verapamil
出版源: 《Indian Journal of Dermatology Venereology & Le... ,2008 ,74 (4) :343
摘要:bBackground/b : The calcium channel blocker, verapamil stimulates procollagenase synthesis in keloids and hypertrophic scars. b Aim/b : To study the effect of verapamil in the treatment of hypertrophic scars and keloids and to evaluate the effect of verapamil on the rate of reduction of hypertrophic scars and keloids in comparison with triamcinolone. b Methods/b : The study was a randomized, single blind, parallel group study in which 54 patients were allocated to to receive either verapamil or triamcinolone. Drugs were administered intralesionally in both groups. Improvement of the scar was measured using modified Vancouver scale and by using a centimeter scale serially till the scar flattened. b Results/b : There was a reduction in vascularity, pliability, height and width of the scar with both the drugs after 3 weeks of treatment. These changes were present at one year of follow-up after stopping treatment. Scar pigmentation was not changed desirably by either drug. Length of the scars was also not altered significantly by either drug. The rate of reduction in vascularity, pliability, height and width of the scar with triamcinolone was faster than with verapamil. Adverse drug reactions were more with triamcinolone than with verapamil. b Conclusion/b : Intralesional verapamil may be a suitable alternative to triamcinolone in the treatment of hypertrophic scars and keloids.
大小:247 kb
下载: 点击下载
预览:

浏览器不支持嵌入PDF阅读,打开新页面在线阅读

本页内容由网络收集而来,版权归原创者所有,如有侵权请及时联系