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标题:Is pain relief equally efficacious and free of side effects with repeated doses of oral sucrose in preterm neonates?
时间:2020-03-26 20:01:20
DOI:10.1016/j.pain.2007.07.032
PMID:17854995
作者:Cláudia Maria Gaspardo;Catia Isumi Miyase;Juliana Thomazatti Chimello
关键词:Pain;Sucrose;Repeated doses;Preterm;Very low birth weight;NICU
出版源: 《Pain®》 ,137 (1) :0-25
摘要:The aim of the present study was to examine the efficacy and potential side effects of repeated doses of oral sucrose for pain relief during procedures in NICU. Thirty-three preterm neonates were randomly allocated in blind fashion into two groups, the sucrose group (SG = 17) and the control group (CG = 16). The responses of neonates to pain and distress were assessed during blood collection on four consecutive assessment (ass.) days. For the first assessment, the neonates did not receive any solution before the blood collection procedure. During the next three days, the SG received oral sucrose (25%; 0.5 ml/kg) and the CG received sterile water, 2 min before each minor acute painful procedure. The neonates were evaluated during blood collection each morning. The assessment was divided into five phases: Baseline (BL), Antisepsis (A), Puncture (P), Dressing (D), and Recovery (R). The neonates' facial activity (NFCS), behavioral state, and heart rate were evaluated. The data analysis used cut-off scores for painful and distressful responses. No side effects of using sucrose were detected. There were significantly fewer SG neonates with facial actions signaling pain than CG neonates in P (ass.2) and in A (ass.3). We found significantly fewer SG neonates in the awake state than CG neonates in P (ass.2 and ass.4). There were significantly fewer SG neonates crying during A (ass.2), P (ass.2 and ass.4), and D (ass.3). There was no statistical difference between-groups for physiological response. The efficacy of sucrose was maintained for pain relief in preterm neonates with no side effects. (C) 2007 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
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目录:
  • Is pain relief equally efficacious and free of side effects with repeated doses of oral sucrose in preterm neonates?
    • Introduction
    • Methods
      • Study design
      • Sample
      • Ethical approval
      • Measures and procedure
      • Data analysis
    • Results
      • Characteristics of preterm infants and neonatal health status
      • Possible side effects during the intervention schedule with sucrose
      • Comparison of behavioral and physiological pain responses between groups - sucrose group vs. control group
      • Characteristics of the Puncture phase procedure
    • Discussion
    • Acknowledgement
    • References

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