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标题:Performance indicators for carrier-based DPIs: Carrier surface properties for capsule filling and API properties for in vitro aerosolisation
时间:2020-03-26 19:40:39
DOI:10.1016/j.ijpharm.2017.12.004
作者:Faulhammer, E.;Zellnitz, S.;Wutscher, T.
出版源: International Journal of Pharmaceutics ,2017
大小:2113 kb
页数:11 PAGES
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目录:
  • Performance indicators for carrier-based DPIs: Carrier surface properties for capsule filling and API properties for in vitro aerosolisation
    • Introduction
    • Materials and methods
      • Materials
      • Particle engineering
        • Engineering of carrier particles via wet decantation
        • Engineering of API particles
      • Characterisation of engineered particles
        • Scanning electron microscopy (SEM)
        • Particle size characterisation
        • Bulk density and tapped density
        • Powder rheometry
      • Preparation of adhesive mixtures
      • Capsule filling
      • Pre-weighing and identification of capsules
      • Blend uniformity during filling
      • Aerodynamic assessment of particles
      • High-performance liquid chromatography (HPLC) analysis
    • Results and discussion
      • Characterisation of engineered API particles
      • Characterisation of engineered carrier particles
      • Characterisation of powder blends
      • Bulk powder and flowability properties of the blends
      • Impact of particle engineering on processability – capsule filling performance
      • Impact of particle engineering on the in vitro aerodynamic performance
    • Conclusion
    • Acknowledgements
    • References

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