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标题:HandaPhos: A General Ligand Enabling Sustainable ppm Levels of Palladium-Catalyzed Cross-Couplings in Water at Room Temperature.
时间:2020-03-26 13:29:34
DOI:10.1002/anie.201510570
PMID:26924396
作者:Handa, Sachin;Andersson, Martin P.;Gallou, Fabrice
关键词:E-Faktor;Ligandendesign;Mizellare Katalyse;Nachhaltige Chemie;Suzuki-Miyaura-Kupplungen
出版源: 《Angewandte Chemie》 ,55 (16) :4914-4918
摘要:The new monophosphine ligand HandaPhos has been identified such that when complexed in a 1:1 ratio with Pd(OAc)2, enables Pd-catalyzed cross-couplings to be run using ≤1000 ppm of this pre-catalyst. Applications to Suzuki–Miyaura reactions involving highly funtionalized reaction partners are demonstrated, all run using environmentally benign nanoreactors in water at ambient temperatures. Comparisons with existing state-of-the-art ligands and catalysts are discussed herein.
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