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标题:Elevated expression of TSLP and IL-33 in Behçet's disease skin lesions: IL-37 alleviate inflammatory effect of TSLP.
时间:2020-03-26 13:14:36
DOI:10.1016/j.clim.2018.03.016
PMID:29631029
作者:Kacem, Olfa; Kaabachi, Wajih; Dhifallah, Imen Ben
出版源: 《Clinical Immunology》 :S1521661616306325
摘要:The release of TSLP and IL-33 affect the skin integrity, which unsettled transcription factor regulators. We investigate TSLP and IL-33 in Behçet disease (BD) and we prove the effect of the anti-inflammatory cytokine IL-37 in BD skin lesions on TSLP production. TSLP, IL-33 and GATA-3/T-bet, were measured using PCR in BD skin lesions. We tested the suppressive effect of IL-37 on skin samples stimulated with a cytokine mixture inducing TSLP expression. TSLP and IL-33 were increased in BD patients particularly in patients having skin manifestations and correlate with indexed skin lesions. TSLP expression in BD with skin lesions correlates significantly with the transcription factors GATA3/Tbet ratio. The anti-inflammatory mediator IL-37 acted as a suppressor of TSLP-skin synthesis. The microenvironment in cutaneous lesions of BD patients' skin lesions is dominated by the expression of IL-33 and TSLP along an inflammatory Th2-type current. IL-37 acts as a booster to restore homeostasis.
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目录:
  • Elevated expression of TSLP and IL-33 in Behçet's disease skin lesions: IL-37 alleviate inflammatory effect of TSLP
    • Introduction
    • Patients and methods
      • Patients and clinical assessment
      • Biological findings
      • Serum TSLP
      • RNA isolation and RT-PCR
      • TSLP modulation by IL-37 in skin lesions
      • Peripheral blood mononuclear cells
      • Statistical analysis
    • Results
      • TSLP and IL-33 expressions in Behçet's disease
      • Expression transcription factor Th1 (T-bet) and Th2 (GATA-3) in BD skin lesion
      • Recombinant IL-37 modulates TSLP expression in cultured skin lesions
    • Discussion
    • Conclusion
    • Acknowledgments
    • Conflict of interest
    • Informed consent
    • Author contributions
    • Financial disclosure
    • References

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