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标题:Type I IFN is a powerful mucosal adjuvant for a selective intranasal vaccination against influenza virus in mice and affects antigen capture at mucosal level.
时间:2020-03-26 11:49:30
DOI:10.1016/j.vaccine.2004.12.006
PMID:15811645
作者:Laura Bracci; Irene Canini; Simona Puzelli
关键词:Influenza;Intranasal;Type I IFN
摘要:http://linkinghub.elsevier.com/retrieve/pii/S0264410X04009405
大小:505 kb
页数:12 PAGES
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目录:
  • Type I IFN is a powerful mucosal adjuvant for a selective intranasal vaccination against influenza virus in mice and affects antigen capture at mucosal level
    • Introduction
    • Materials and methods
      • Mice
      • Antigen
      • Interferon
      • Intranasal immunizations
      • Tracking of intranasally-delivered solutions
      • Uptake of fluorescently labelled dextran by mucosal phagocytes
      • Determination of influenza-specific antibodies
      • Broncho-alveolar lavage (BAL) and nasal lavage (NL)
      • Virus and virus challenge
      • Statistical analysis
    • Results
      • Type I IFN dose-dependent adjuvant effect in intranasal influenza vaccine delivery
      • A single intranasal type I IFN-adjuvanted influenza vaccine administration results in a sustained Ab production and protection from influenza virus infection
      • Specificity of type I IFN adjuvant effect
      • Adjuvant effect of type I IFN in mice subjected to selective intranasal delivery by fractionated vaccine doses
      • Long term persistence of influenza-specific antibodies: comparison of intranasal immunization in anesthetized versus non-anesthetized mice
      • Secretory IgA induction by type I IFN
      • Distribution of intranasally delivered solutions in anesthetized and non-anesthetized mice and type I IFN effect on antigen capture
    • Discussion
    • Acknowledgements
    • References

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